Description_x000D_ Application_x000D_ Complement factor H (CFH) is a plasma regulator of the complement protein C3b in the alternative pathway of the complement system. Research has shown that binding of CFH is important for pathogenesis of group A streptococcus (GAS), and inhibition of this binding may be an effective management of GAS infections._x000D_ Biochem/physiol Actions_x000D_ Complement factor H plays an essential role in the homeostasis of the complement system and in preventing collateral damage to bystander cells and tissues by complement activation._x000D_ C3b-binding protein which regulates the formation and function of complement C3 and C5 convertases._x000D_ Other Notes_x000D_ View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer