Description General description A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (> 50% remaining after 30 min at 37°C). A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (> 50% remaining after 30 min at 37°C). Packaging 2 mg in Glass bottle Packaged under inert gas Warning Toxicity: Regulatory Review (Z) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Merritt, J., et al. 2006. Bioorg. Med. Chem. Lett.16, 4107.; Description