Description General description A styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor. Packaging 10 mg in Glass bottle Biochem/physiol Actions Cell permeable: yes Primary Target CXCR7 Reversible: yes Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Other Notes Wijtmans, M., et al. 2011, Eur J Med Chem51, 184.; Description