Description_x000D_ General description_x000D_ Cyclophosphamide (CYC) is a cytotoxic alkylating agent. It is activated by the cytochrome P-450 enzyme system in the liver. It has immunomodulatory functionality and inhibits humoral and cellular immunity._x000D_ Application_x000D_ Cyclophosphamide monohydrate has been used:_x000D_ • to test its antitumor effect on TC-1 tumor cells_x000D_ • as a component of multidrug solution for isolation of resistant human burkitt lymphoma cell line_x000D_ • in testing antitumor immunity in mouse tumor cell lines_x000D_ Packaging_x000D_ 1, 5, 10, 25 g in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity._x000D_ Features and Benefits_x000D_ This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC