Description_x000D_ Application_x000D_ Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c._x000D_ The specific sites and extent of oxidation in horse cytochrome c treated with H2O2 and UV were characterized. It was suggested that the state of these sites could be used as a biomarker for the oxidative environment in a cell._x000D_ Packaging_x000D_ 1, 5 g in glass bottle_x000D_ 50, 100, 500 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Cytochrome c is primarily known as an electron-carrying mitochondrial protein. The transition of cytochrome c between the ferrous and ferric states within the cell makes it an efficient biological electron-transporter and it plays a vital role in cellular oxidations in both plants and animals. It is generally regarded as a universal catalyst of respiration, forming an essential electron-bridge between the respirable substrates and oxygen_x000D_ Preparation Note_x000D_ Prepared with acetic acid without using TCA._x000D_ Other Notes_x000D_ View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.