Description Biochem/physiol Actions An important substance implicated in energy metabolism. It is a key node point linking other metabolic processes or pathways. Triosephosphate metabolism can be associated with many metabolic pathways, including glycolysis, pentose phosphate pathway, gluconeogenesis and lipid metabolism, and can also be involved in maintaining hemostasis. The metabolic abnormality of triosephosphate may be tied to many pathophysiological processes, such as triosephosphate isomerase deficiency, hyperglycemia and diabetic nephropathy; review and papers cited therein.