Description_x000D_ Application_x000D_ Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents._x000D_ Packaging_x000D_ 1 g in glass bottle_x000D_ 100 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific._x000D_ Other Notes_x000D_ Keep container tightly closed in a dry and well-ventilated place.