Description_x000D_ Amino Acid Sequence_x000D_ Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys [Disulfide bridges: 2−30; 4−19; 9−29]_x000D_ General description_x000D_ Chemical structure: peptide_x000D_ The α-defensin genes, such as DEFA1 (defensin alpha 1) and DEFA3 (defensin α 3) codes for HNP-1, 2 and 3 (human neutrophil peptides). This gene is mapped to human chromosome 8p23.1._x000D_ Biochem/physiol Actions_x000D_ Human neutrophil peptides (HNPs) is involved in endothelial cell dysfunction at the time of early atherosclerotic development. HNP 1−3 can regulate the growth of atherosclerosis. HNP 1−3 levels are usually high in inflammation, including sepsis and acute coronary vascular disorders._x000D_ This is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils. Defensins are a family of 3-4 kDa (29-34 amino acids) peptides found in the granules of mammalian phagocytes. The members of this family are variably arginine-rich and share six conserved cysteine residues that participate in intramolecular disulfide bonds.