Description_x000D_ Application_x000D_ Dendrotoxin-K is suitable for use as a potassium voltage-gated channel subfamily A member 1 (Kv1.1) channel blocker in axon and human embryonic kidney (HEK293) cells. It has also been used as a selective blocker of Kv channels in mice._x000D_ Biochem/physiol Actions_x000D_ Dendrotoxin-K (DTXk) is isolated from mamba snake Dendroaspis polylepis and interacts with the β-turn region in the N-terminal sequence of the potassium channel. It inhibits tumor progression in gefitinib-resistant non-small cell lung cancer cells. DTXk induces neuronal damage in the hippocampus via N-methyl-d-aspartate (NMDA) and non-NMDA receptors._x000D_ Dendrotoxin-K inhibits potassium channels that contain Kv1.1 protein only._x000D_ Features and Benefits_x000D_ This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here._x000D_ Other Notes_x000D_ Isolated initially from Dendroaspis polylepis polylepis venom_x000D_ Preparation Note_x000D_ Purified by a modification of the method of Schweitz._x000D_ Reconstitution_x000D_ Reconstitute in 1 mL deionized water or buffer (pH 7.5) to yield 10 μM stock