Description_x000D_ General description_x000D_ DES (1-6) IGF-II is a 61 amino acid analog of human insulin-like growth factor II, lacking the first six N-terminal amimo acids. DES (1-6) IGF-II exhibits reduced affinity for IGF binding proteins (IGFBPs), which are known to inhibit the actions of IGF′s._x000D_ Application_x000D_ Used for studies of IGF-II function in cell culture applications. Use in combination with IGF-I, insulin and other forms of IGF-II to study receptor functions and cell signaling._x000D_ Other Notes_x000D_ Recombinant analog of insulin-like growth factor II._x000D_ Preparation Note_x000D_ Prepared from 0.1 M acetic acid._x000D_ Synthesized recombinantly in E. coli using a patented fusion protein expression system, DES (1-6) IGF-II is then purified by liquid chromatography. DES (1-6) IGF-II has been developed as an inexpensive, high quality potent analog of IGF-II for use as a growth factor supplement in cell culture. DES (1-6) IGF-II is supplied as a powder, lyophilized from 0.1 M acetic acid. Molecular weight is 6,765 daltons.