Description_x000D_ Amino Acid Sequence_x000D_ Glp-His-Trp-Ser-Tyr-His(Bzl)-Leu-Arg-Pro-NHEt_x000D_ Application_x000D_ [des-Gly10, D-His(Bzl)6]-LH-RH ethylamide has been used:_x000D_ • for inducing Batrachoseps gravid females to oviposit_x000D_ • for comparing the effect of LHRH (luteinizing hormone-releasing hormone) agonists and dopamine antagonists in Lithobates pipiens_x000D_ • for inducing oviposition in females of Taricha granulosa and Ensatina eschscoltzii_x000D_ • to induce spawning in Spea hammondii adults_x000D_ Biochem/physiol Actions_x000D_ Glp-His-Trp-Ser-Tyr-His(Bzl)-Leu-Arg-Pro-NHEt ([des-Gly10, D-His(Bzl)6]-LH-RH) is a GnRH (gonadotropin-releasing hormone) agonist, histerelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Histerelin is used for the treatment of central precocious puberty in children. It inhibits actions of sex steroids on the male and female reproductive organs._x000D_ Features and Benefits_x000D_ Has greater lipophilicity than other LH-RH agonists, but retains high water solubility