Description_x000D_ Application_x000D_ Dihydrocapsaicin has been used:_x000D_ • as a standard to analyze the level of dihydrocapsaicin in endogenous An2 and capsaicin synthase silenced fruits_x000D_ • as an external standard to determine the variability in capsaicinoid content in different landraces of capsicum_x000D_ • in the activation or ablation of capsaicin-sensitive primary afferents (CSPA) fibres_x000D_ Packaging_x000D_ 1 g in glass bottle_x000D_ 250 mg in glass bottle_x000D_ 50 mg in poly bottle_x000D_ Biochem/physiol Actions_x000D_ Dihydrocapsaicin/8-methyl-N-vanillylnonanamide; N-[−4-hydroxy-3-methoxybenzyl] 8-methylnonanamide (DHC) is an active component of capsaicinoids in chili peppers. DHC is capable of reducing body temperature. Hence it is considered as a pharmaceutical-induced hypothermia (PIH) candidate to treat cardiac arrest (CA) patients. It may possess anti-cancer, anti-inflammation, antioxidant, anti-obesity properties. DHC might help in the reduction of oxidative stress and inflammation in ischemia and reperfusion (I/R) injury. DHC can repress nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway._x000D_ VR1 vanilloid receptor agonist._x000D_ Features and Benefits_x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ Linkage_x000D_ Capsaicin analog._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC