Description_x000D_ General description_x000D_ Cadherin-1 (CDH1) is a transmembrane protein, which is mainly involved in cell adhesion in normal epithelia. The associated gene is mapped to human chromosome 16q22.1._x000D_ Biochem/physiol Actions_x000D_ Cadherin-1 (CDH1) stabilizes the cell adhesion in normal cells and also helps in signaling via association with β catenin. Mutations in the CDH1 gene are linked with oral clefts in the Thai population. CDH1 works as a tumor suppressor in various cancers. Low expression of CDH1 increases cellular invasive and metastatic potential. For instance, low expression of this gene is associated with poor survival of patients with esophageal cancer._x000D_ Physical form_x000D_ Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization._x000D_ Reconstitution_x000D_ Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.