Description_x000D_ General description_x000D_ Elastin is an extracellular matrix protein encoded by the gene ELN, which is mapped to human chromosome 7q11.23. Elastin is a major protein component of elastic fibres and is synthesized from the precursor protein called tropoelastin. Elastin is present in all the vertebrates except for the primitive fish. Elastin is majorly composed of glycine, proline and other hydrophobic residues._x000D_ Application_x000D_ Elastin from human skin has been used as a substrate for the enzyme reaction with age-related NADH oxidase (arNOX) using fluorescein-conjugated tyramine._x000D_ Elastin is a structural protein which has been used in studies of chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD._x000D_ Biochem/physiol Actions_x000D_ Elastin is essential for resilience of arteries, and other elastic tissues like lungs and skin. Polymorphism in ELN gene causes intracranial aneurysm. Loss of function or haploinsufficiency of ELN gene leads to supravalvular aortic stenosis (SVAS). Frameshift mutations in ELN gene is implicated in congenital cutis laxa resulting in skin laxity and affect pulmonary and cardiovascular system._x000D_ Preparation Note_x000D_ Prepared under mild extraction conditions to minimize peptide bond cleavage as described by Starcher, et al._x000D_ Analysis Note_x000D_ Final purity determined by amino acid analysis and the percent insoluble residue remaining after digestion with porcine elastase.