Description_x000D_ General description_x000D_ Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards._x000D_ Erythromycin is a complex macrolide antibiotic drug that exhibits a bacteriostatic activity. It is generally employed in human and veterinary medicines owing to its potential activity against gram positive and a few gram negative strains._x000D_ Application_x000D_ Erythromycin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques._x000D_ These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements._x000D_ Biochem/physiol Actions_x000D_ Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex._x000D_ Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria._x000D_ Caution_x000D_ This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C._x000D_ Preparation Note_x000D_ This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light._x000D_ Footnote_x000D_ To see an example of a Certificate of Analysis for this material enter LRAC3047 in the slot below. This is an example certificate only and may not be the lot that you receive._x000D_ Legal Information_x000D_ Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards._x000D_ These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).