Description_x000D_ General description_x000D_ MISSION esiRNA are endo-ribonuclease prepared siRNA. MISSION esiRNA are a heterogeneous mixture of siRNAs that all target the same mRNA sequence. These multiple silencing triggers lead to highly specific and effective gene silencing._x000D_ To view this esiRNA screening tutorial, vist._x000D_ esiRNA Custom options:_x000D_ ESISEC: Secondary independent esiRNA for any human or mouse esiRNA_x000D_ ESIOPEN: Custom esiRNA targeting species specific sequence provided_x000D_ Contact your local sales rep. or email us at Custom esiRNA for more information._x000D_ Biochem/physiol Actions_x000D_ CHAF1A (chromatin assembly factor 1 subunit A) is one of the subunits of CAF1 complex, a histone chaperone responsible for the positioning of histone H3 and H4 dimers into nucleosomes. CAF1 is needed for S-phase progression, heterochromatin formation and chromatin restoration after DNA repair. CAF1A is required for promoting protein and chromosome associations with nucleoli. It is required for cell proliferation and is upregulated in colon cancer and aggressive neuroblastoma._x000D_ Physical form_x000D_ Solution in low-TE (Tris-HCl (10 mM final), EDTA (1 mM final), pH to 8.0._x000D_ Legal Information_x000D_ MISSION is a registered trademark of Sigma-Aldrich Co. LLC