Description_x000D_ General description_x000D_ MISSION esiRNA are endo-ribonuclease prepared siRNA. MISSION esiRNA are a heterogeneous mixture of siRNAs that all target the same mRNA sequence. These multiple silencing triggers lead to highly specific and effective gene silencing._x000D_ esiRNA Custom options:_x000D_ ESISEC: Secondary independent esiRNA for any human or mouse esiRNA_x000D_ ESIOPEN: Custom esiRNA targeting species specific sequence provided_x000D_ Contact your local sales rep. or email us at Custom esiRNA for more information._x000D_ Biochem/physiol Actions_x000D_ PPARGC1A (peroxisome proliferator-activated receptor γ coactivator 1-α) is a transcriptional regulator which plays a key role in insulin signaling and mitochondrial regulation. It controls metabolism in many organs. For instance, it regulates gluconeogenesis in hepatocytes, thermogenesis in brown adipose tissue, and mitochondrial biogenesis and fatty acid oxidation in the heart. PPARGC1A also attenuates oxidative damage. Mutations in this gene are associated with type 2 diabetes mellitus. It is downregulated in prostate cancer. Presence of PPARGC1A inhibits prostate cancer progression and metastasis. However, presence of this protein gives selective advantages in breast cancer and melanoma cells._x000D_ Physical form_x000D_ Solution in low-TE (10 mM Tris-HCl, pH 8.0, 1 mM EDTA)_x000D_ Other Notes_x000D_ View the esiRNA screening tutorial._x000D_ Legal Information_x000D_ MISSION is a registered trademark of Sigma-Aldrich Co. LLC