Description_x000D_ General description_x000D_ Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase._x000D_ Application_x000D_ Estrone has been used:_x000D_ • as medium supplement for hormone based degranulation studies of natural killer cells_x000D_ • as an endocrine disrupting compound for screening bacterial biosensor in toxic water._x000D_ • as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines_x000D_ Packaging_x000D_ 1, 5, 25 g in glass bottle_x000D_ 500 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone._x000D_ Features and Benefits_x000D_ This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC