Description General description A cell-permeable carbamate compound that acts as a potent, selective, and irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.6 nM in brain membranes). Shown to block anandamide (Cat. No. 172100) breakdown in rat cortical neurons (IC50 = 500 pM) and modulate anxiety in rats (ID50 = 0.15 mg/Kg). Does not affect the activities of several serine hydrolases (IC50 > 30 µM), including AChE (acetylcholinesterase), BCh (butyrylcholinesterase) and MGL (monoglyceride lipase). It also does not interfere with the binding of anandamide to cannabinoid receptors CB1 and CB2 (IC50 > 100 µM), as well as several ion-channels and neurotransmitter transporters. A cell-permeable, carbamate compound that acts as a potent, selective, and irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.6 nM in brain membranes). Shown to block anandamide (Cat. No. 172100) breakdown in rat cortical neurons (IC50 = 0.5 nM) and modulate anxiety in rats (ID50 = 0.15 mg/Kg). Does not affect the activities of several serine hydrolases, namely, AchE (acetyl cholinesterase) (IC50 > 100 µM), BCh (butyryl cholinesterase) (IC50 > 100 µM), and MGL (monoglyceride lipase) (IC50 > 30 µM). Does not interfere with the binding of anandamide to cannabinoid receptors, CB1 and CB2 (IC50 > 100 µM), several ion-channels, or neurotransmitter transporters. Packaging 5 mg in Alu drum Biochem/physiol Actions Cell permeable: yes Primary Target FAAH Product does not compete with ATP. Reversible: no Target IC50: 4.6 nM against FAAH Packaging Packaged under inert gas Warning Toxicity: Toxic (F) Reconstitution Following reconstitution aliquot, purge with an inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Other Notes Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. Kathuria, S., et al. 2003. Nat. Med.9, 76.; Description