Description_x000D_ General description_x000D_ Factor V, a glycoprotein is usually seen in the alpha granules of platelets and in plasma._x000D_ Factor Va is the activated form of factor V and the cofactor of Xa. It is a component of the prothrombinase complex._x000D_ Biochem/physiol Actions_x000D_ Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. It has been used in studies of coagulopathic bleeding which occurs following injury and is a leading cause of hospital deaths._x000D_ Factor Va serves as a receptor and positive effector of factor Xa. Hence it can efficiently help in the conversion of prothrombin to thrombin._x000D_ Linkage_x000D_ View this factors role in the Coagulation Cascade_x000D_ Unit Definition_x000D_ One unit is equivalent to the Factor V activity in 1.0 mL of normal human plasma at pH 7.4 at 37 °C._x000D_ Physical form_x000D_ Aqueous solution containing 50% (v/v) glycerol and 5mM CaCl2