Description_x000D_ General description_x000D_ Fetuin from fetal bovine serum is a plasma glycoprotein. It is a 64 kDa glycoprotein, which is produced by the liver and adipose tissue._x000D_ Application_x000D_ Fetuin from fetal bovine serum has been used:_x000D_ • as a substrate to determine neuraminidase activity_x000D_ • to validate the specificity of sialidases_x000D_ • to stabilize m-calpain_x000D_ Packaging_x000D_ 1, 5, 25 g in poly bottle_x000D_ 100 mg in poly bottle_x000D_ Biochem/physiol Actions_x000D_ Fetuin acts as an inhibitor of insulin receptor tyrosine kinase. It modulates bone remodeling and calcium metabolism. Fetuin regulates vascular calcification, insulin resistance, protease activity control, keratinocytes migration and breast tumor cell proliferative signaling. It functions as a biomarker for neurodegenerative diseases. Fetuin exhibits anti-inflammatory property._x000D_ Preparation Note_x000D_ Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).