Description_x000D_ General description_x000D_ FGF10 (fibroblast growth factor 10) is a member of the FGF protein family, which is a mitogen of epithelial origin and has a paracrine activity. It is produced by mesenchymal lineage cells, and acts as a ligand for FGFR, most notably FGFR2b, which is expressed by epithelial cells._x000D_ Application_x000D_ Fibroblast Growth Factor-10 human is suitable for culturing of HUVEC cell line (human umbilical vein endothelial cells) to determine the anti-angiogenic properties of sFLT-1 (soluble fms-related tyrosine kinase-1)._x000D_ Biochem/physiol Actions_x000D_ FGF10 (fibroblast growth factor 10) is involved in cell growth, morphogenesis and embryogenesis. It plays an essential role in initiating the formation of limb bud, lung morphogenesis and brain formation during embryogenesis. It acts as a mitogen, where it facilitates the regeneration of epithelia post-bladder urothelial injury. Thus, it might have future applications during bladder transplantation. Studies in Japanese population show that polymosphisms- rs339501, rs12517396, and rs10462070 are linked with severe myopia, and might act as susceptibility factors for the same. In lung cancer cells, FGFR4 reduces the stem cell/self-renewal property of cancer cells, and makes them more susceptible to chemotherapy._x000D_ Physical form_x000D_ Lyophilized from a 0.2 μm filtered solution in 20 mM MOPS, 50 mM sodium sulfate, 1 mM DTT, 0.5 mM EDTA, pH 7.2, containing 50 μg bovine serum albumin per 1 μg cytokine._x000D_ Analysis Note_x000D_ The biological activity is measured by its ability to stimulate the proliferation of a monkey epithelial cell line 4MBr-5.