Description_x000D_ General description_x000D_ TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke._x000D_ Physical form_x000D_ Lyophilized from PBS._x000D_ Reconstitution_x000D_ Reconstitute with 50 μL deionized water._x000D_ Other Notes_x000D_ The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.