Description General description A highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM. Packaging 250 μg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target FTase in vitro Product does not compete with ATP. Reversible: no Target IC50: 500 pM against FTase in vitro Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Physical form Supplied as a trifluoroacetate salt. Reconstitution Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C. Other Notes Lantry, L.E., et al. 2000. Carcinogenesis21, 113. Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802. Sun, J., et al. 1995. Cancer Res. 55, 4243.; Description