Description_x000D_ Application_x000D_ γ-Aminobutyric acid (GABA) has been used:_x000D_ • in the preparation of GABA–BSA (bovine serum albumin)–GA (glutaraldehyde) conjugate, which is used as a control for GABA immunostaining_x000D_ • in the macromolecule suppressed detection of GABA by magnetic resonance spectroscopy (MRS)_x000D_ • in the intraintestinal application of GABA in order to increase intraluminal fluid secretion_x000D_ Biochem/physiol Actions_x000D_ GABA (γ-Aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the central nervous system and also functions as a neuromodulator in some peripheral tissues. It binds to GABAA receptor and inhibits the activity of signal-receiving neurons. The GABAA receptors are found to form a channel in the cell membranes of neurons. Upon binding of GABA, the receptor is activated to allow the passage of negatively charged molecules, such as chloride ions, into the cell. This results in lowering of excitability of the cell._x000D_ GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation, and anaesthetics. GABA can also influence heart rate and blood pressure._x000D_ Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl− conductance._x000D_ Features and Benefits_x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC