Description_x000D_ General description_x000D_ GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques._x000D_ The gene encoding growth hormone receptor (GHR or GHBP) is localized on human chromosome 5p13.1-p12, with nine exons. It possesses a cytoplasmic and an extracellular domain for protein binding._x000D_ Physical form_x000D_ GHBP was lyophilized from a concentrated (1 mg/ml) solution with 0.0045 mM NaHCO3._x000D_ Reconstitution_x000D_ Centrifuge the vial prior to opening. Avoid freeze-thaw cycles._x000D_ Reconstitute in sterile dH2O not less than 100 μg/ml. This solution can then be diluted into other aqueous buffers.