Description_x000D_ Amino Acid Sequence_x000D_ His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr_x000D_ General description_x000D_ Glucagon is a peptide hormone of 29 amino acids secreted by alpha cells in the pancreas. Its release is controlled by hypothalamus when glucose levels in the blood decreases. The C-terminal region of glucagon is crucial for receptor binding._x000D_ Application_x000D_ Glucagon has been used:_x000D_ • in the stimulation of human primary hepatocytes for cyclic adenosine monophosphate (cAMP) production_x000D_ • for measuring glucagon response in mice_x000D_ • to induce gluconeogenic stimuli in primary hepatocytes_x000D_ Packaging_x000D_ 1, 5, 25 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Glucagon functions to elevate glucose by activating GCGR in liver mediating the glucose circulation in blood. The hyperglucagonemia elevated levels of glucagon is observed in diabetes and in nonalcoholic fatty liver disease, post gastric bypass surgery and glucagon based tumors._x000D_ Components_x000D_ H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl_x000D_ Other Notes_x000D_ This product is a chemically synthesized glucagon qualified for use in cell culture applications._x000D_ Physical form_x000D_ powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw