Description_x000D_ General description_x000D_ Glyoxalase detoxification system consists of glyoxalase (GLO)-I and GLO-II. GLO-I is a cytosolic, 42 kDa, dimeric Zn2+ metalloenzyme._x000D_ Packaging_x000D_ 500, 1000, 2500 units in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Glyoxalase I is universally expressed and involved in the protection against cellular damage due to cytotoxic metabolites such as advanced glycation end products (AGEs). It is an integral component of the detoxification system, catalyzing the conversion of reactive, acyclic a-oxoaldehydes into the corresponding a-hydroxyacids in a glutathione-dependent manner._x000D_ Unit Definition_x000D_ One unit will form 1.0 μmole of S-lactoylglutathione from methylglyoxal and reduced glutathione per min at pH 6.6 at 25 °C._x000D_ Physical form_x000D_ Solution in 50% glycerol, 0.4 M (NH4)2SO4 and 0.002 M KH2PO4 pH 6.5_x000D_ Analysis Note_x000D_ Protein determined by biuret.