Description_x000D_ Application_x000D_ GMX1778 has been used as NAMPT inhibitor, to study its effects on nicotinamide adenine dinucleotide (NAD) contents of SH-SY5Y cells exposed to Vacor._x000D_ Packaging_x000D_ 5, 25 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ GMX1778 (CHS-828) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) that exhibits a potent anticancer activity both in vitro and in vivo. GMX1778 exerts a cytotoxic effect by decreasing the cellular level of NAD+. GMX1778 increases intracellular ROS in cancer cells but does not induce ROS in normal cells._x000D_ GMX1778 can regulate redox status and has the ability to simulate ROS in cancer cells.