Description General description A potent, cell-permeable, and irreversible inhibitor of Group III caspases (caspase-6, -8, -9, and -10), although more effective towards caspases-6 and -8. Also inhibits caspase-1 and caspase-3. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A potent, cell-permeable, and irreversible inhibitor of Group III caspases (caspases-6, -8, -9, and -10), although more effective towards caspases -6 and -8. Also inhibits caspase-1 and caspase-3. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target caspase-1, caspase-3, caspase-6, caspase-8, caspase-9, caspase-10 Product does not compete with ATP. Reversible: no Warning Toxicity: Standard Handling (A) Sequence Z-Ala-Glu(OMe)-Val-Asp(OMe)-CH₂F* Reconstitution Following reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Analysis Note Single spot by TLC Other Notes Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.; Description