Description_x000D_ General description_x000D_ PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade._x000D_ Packaging_x000D_ 100 g in poly bottle_x000D_ 5, 25, 50 kg in poly drum_x000D_ Application_x000D_ Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary._x000D_ Linkage_x000D_ Enhanced Quality Product Documentation on PharmaGrade Guanidine Hydrochloride