Description_x000D_ Application_x000D_ Guanosine 5′-triphosphate sodium salt hydrate has been used:_x000D_ • in the preparation of horseradish peroxidase (HRP)-modified platination reagents_x000D_ • in whole cell, voltage-clamp recordings_x000D_ • in in vitro inhibition of transglutaminase (tTG)_x000D_ Packaging_x000D_ 1 g in poly bottle_x000D_ 10, 25, 100, 250 mg in poly bottle_x000D_ Biochem/physiol Actions_x000D_ GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA._x000D_ Features and Benefits_x000D_ This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ Preparation Note_x000D_ Prepared by enzymatic phosphorylation of 5′-GMP.