Description General description A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits protein kinase A (Ki = 1.2 µM), myosin light chain kinase (Ki = 68 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM). A potent, cell-permeable, reversible, and ATP-competitive, and highly active inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits myosin light chain kinase (Ki = 68 µM), protein kinase A (Ki = 1.2 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM). Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Product competes with ATP. Reversible: yes Target Ki: 68 µM against MLCK Warning Toxicity: Standard Handling (A) Preparation Note Further dilute with aqueous buffer just prior to use. Other Notes Ido, M., et al. 1991. Br. J. Cancer 64, 1103. Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523. Inagaki, M., et al. 1986. Mol. Pharmacol.29, 577. Hidaka, H., et al. 1984. Biochemistry23, 5036.; Description