Description_x000D_ General description_x000D_ Hemoglobin is the major component of red blood cells and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is a globular protein with α and β chains with every 141 and 146 amino acids respectively. It exists as a tetramer with each monomer having heterocyclic porphyrin ring with iron constituting the heme._x000D_ Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide._x000D_ Application_x000D_ Hemoglobin from bovine blood has been used as a substrate in cathepsin D activity assay. It has also been used to measure the activity of acid proteases (pepsin-like) in the stomach extract._x000D_ The solubility of α-elastin has been applied to construction of elastin-mimetic biomaterials._x000D_ Packaging_x000D_ 1 kg in poly drum_x000D_ 25, 100 g in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Bovine hemoglobin is used in the production of hemoglobin-vesicles (HbV). It has high thermal stability and high oxygen affinity when compared to human hemoglobin. Bovine hemoglobin interacts with synthetic and azo dyes. Polymerized forms of bovine hemoglobin are used to treat autoimmune hemolytic anemia._x000D_ Oxygen transporter. The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation; deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues._x000D_ Caution_x000D_ Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin._x000D_ Preparation Note_x000D_ Prepared from washed, lysed and dialyzed erythrocytes.