Description_x000D_ General description_x000D_ Histamine dihydrochloride is a derivative of histamine. It prevents the formation of ROS (reactive oxygen species), which inhibits the activation of T cells and natural killer cells. Histamine dihydrochloride is implicated in tumor cell apoptosis. It prevents the relapse of acute myeloid leukemia in patients._x000D_ Application_x000D_ Histamine dihydrochloride has been used:_x000D_ • as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)_x000D_ • to determine its level in fish using HPLC (high performance liquid chromatography)_x000D_ • to assess the tracheal response to antigens in guinea-pigs_x000D_ Packaging_x000D_ 10 mg in glass bottle_x000D_ 10, 25 g in poly bottle_x000D_ 5 g in glass bottle_x000D_ Features and Benefits_x000D_ This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC