Description General description A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells. A cell-permeable, amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylase (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells. Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target Rat liver HDAC Product does not compete with ATP. Reversible: no Target IC50: 40 nM for rat liver HDAC Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Other Notes Ramiszewski, S.W., et al. 2002. J. Med. Chem.45, 753. Jung, M., et al. 1999. J. Med. Chem.42, 4669.