Description_x000D_ General description_x000D_ HSP70 is a member of the heat shock protein family and is synthesized by cells of many organisms in response to stress. HSP70 is found mostly but not exclusively in the nucleus of unstressed cells. For several hours after a short heat shock, however, it is strongly concentrated in nucleoli. Nucleoli are transiently damaged by such a heat shock: their morphology changes and assembly and export of ribosomes is blocked for several hours. HSP70 helps to stabilize the morphological changes of the nucleoli._x000D_ HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) is also termed as HSP72. It belongs to the molecular chaperones family. This gene is located on human chromosome 6p21._x000D_ Biochem/physiol Actions_x000D_ HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) participates in several cellular processes, such as thermotolerance, clearance of protein aggregate, survival and proliferation. Mutation in Hsp70 gene locus is linked with systemic lupus erythematosus. Overexpression of this protein is observed in valproic acid (VPA)-resistant cell lines._x000D_ Physical form_x000D_ Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol._x000D_ Preparation Note_x000D_ After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.