Description_x000D_ General description_x000D_ The gene encoding arginase 1 (ARG1), spanning 10-15kb on genomic DNA, is localized on human chromosome 6q23.2. It consists of eight exons. The protein consists of 322 amino acids and is expressed in the liver, red blood cells, lactating mammalian glands and the kidney._x000D_ Application_x000D_ For research use only. Not for use in diagnostic procedures._x000D_ Please refer to the attached Protocolfor details._x000D_ Biochem/physiol Actions_x000D_ Arginase 1 (ARG1) is a liver enzyme involved in the hydrolysis of arginine to form ornithine and urea. In addition to urea cycle, ARG1 is also implicated in various cellular processes, such as macrophage-mediated cytotoxicity and regulation of immune response. The encoded protein is also involved in allergen challenged lungs, in autoimmune inflammation in the central nervous system and in acute liver injury. Deficiency or mutations in the gene leads to a rare urea cycle disorder, argininemia._x000D_ Other Notes_x000D_ A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.