Description_x000D_ General description_x000D_ The Human CD26 (also known as DPPIV) ELISA (Enzyme- Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human CD26 in serum, plasma, cell culture supernatants and urine._x000D_ Immunogen_x000D_ Recombinant Human CD26_x000D_ Application_x000D_ For research use only. Not for use in diagnostic procedures._x000D_ Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)_x000D_ Biochem/physiol Actions_x000D_ Dipeptidyl peptidase 4 (DPPIV), also known as CD26 (cluster of differentiation 26), is localized on T- cell surface and interacts with adenosine deaminase (ADA), collagen and CD459. It plays a vital role in T cell co-stimulation, cell-to-cell adhesion, and in human immunodeficiency virus (HIV) infection. Deletion of the DPPIV gene alters carbohydrate metabolism which in turn leads to mental retardation and hypotonia. Abnormal expression of DPPIV is observed during liver regeneration, human cirrhosis and liver tumorigenesis. DPPIV level is reduced in serum of chronic obstructive pulmonary disease (COPD) patients, hence, this protein has potential as a serologic marker for screening COPD. DPP4 functions as a serine protease enzyme that catalyzes the cleavage of dipeptides from peptides containing proline or alanine residues. IL-13 induced DPPIV expression is upregulated in bronchial epithelial cells (BECs) and this expression might contribute to the development of asthmatic airway inflammation, cell proliferation and fibronectin (FN) production. This protein is a promising biomarker and therapeutic target for asthma._x000D_ Other Notes_x000D_ A sample Certificate of Analysis is available for this product._x000D_ Please type the word sample in the text box provided for lot number.