Description_x000D_ General description_x000D_ The antibody pair provided in this kit recognizes human Coagulation Factor III/Tissue Factor._x000D_ Tissue factor (TF), also known as coagulation factor III (F3), is encoded by the gene mapped to human chromosome 1p21.3. TF has been shown to exist in two forms, namely membrane-bound and soluble TF. The encoded protein contains an extracellular domain (ED), a single transmembrane domain (TD) and short cytoplasmic domain (CD)._x000D_ Application_x000D_ Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)_x000D_ Human F3 / Tissue Factor ELISA Kit has been used to measure the concentration of soluble tissue factor (TF) expressed in human umbilical vein smooth muscle cells (HUVSMCs)._x000D_ Biochem/physiol Actions_x000D_ Tissue factor (TF) interacts with the zymogen factor VII (VII) and its activated form VIIa, and initiates blood coagulation protease cascade. The encoded protein is involved in the pathogenesis of cardiovascular diseases, such as hypertension, atherosclerosis, acute coronary syndrome and restenosis. Thus, it is considered to be a potential therapeutic target for cardiovascular diseases.