Description_x000D_ General description_x000D_ Interleukin-21 (IL-21) is a pleiotropic cytokine. It belongs to the common γ-chain cytokines with broad pleiotropic actions. This gene is located on human chromosome 4q27._x000D_ Application_x000D_ Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)_x000D_ Biochem/physiol Actions_x000D_ Interleukin-21 (IL-21) regulates chronic viral infection, thereby plays a major role for immune responses in a mouse model of HBV (hepatitis B virus) infection. This gene is linked to celiac disease, rheumatoid arthritis (RA), type 1 diabetes mellitus (type 1 DM) and psoriatic arthritis. IL-21 has the ability to promote maturation and increase the cytotoxicity of CD8+ T cells and natural killer (NK) cells._x000D_ The antibody pair provided in this kit recognizes Human Interleukin-21._x000D_ Other Notes_x000D_ A sample Certificate of Analysis is available for this product._x000D_ Please type the word sample in the text box provided for lot number.