Description General description A naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Acts as a selective and direct inhibitor of IκB kinase (IC50 = 24 µM) in TNF-α stimulated HeLa cells thereby prevents NF-κB activation. Also inhibits the production of nitric oxide in IL-1β or IL-17 stimulated normal human chondrocytes. Does not inhibit the activities of JNK and p38MAPK. Reported to be effective against murine blood and liver stages of malarial parasites. Inhibits VEGF-induced cell proliferation in vitro (IC50 = 28.6 µM) and bFGF-induced angiogenesis in the chick chorioallantoic membrane (IC50 = 10 µM). A naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Acts as a selective and direct inhibitor of IκB kinase (IC50 = 24 µM) in TNF-α stimulated HeLa cells, thereby preventing NF-κB activation. Also inhibits the production of nitric oxide by IL-1β or IL-17 stimulated normal human chondrocytes. Reported to neither affect the synthesis of prostaglandin nor inhibit the activities of JNK and p38MAPK. Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target IKB Kinase Product does not compete with ATP. Reversible: no Target IC50: 24 µM against IκB kinase Packaging Packaged under inert gas Warning Toxicity: Harmful (C) Reconstitution Following reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 weeks at -20°C. Stock solutions in ethanol are stable for up to 2 months at -20°C. Other Notes Pulai, J.I., et al. 2005. J. Immunol.174, 5781. Ojo-Amaize, E. A., et al. 2002. Cancer Res.62, 4007. Ojo-Amaize, E.A., et al. 2001. Cell Immunol.209, 149.