Description General description A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (< 50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt. A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence, linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IkB kinases (IKK) in RAW 264.7 cells (<50 μg/ml) and prevents NF-κB activation. Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target LPS-induced IκB degradation by IKK in RAW 264.7 cells Product does not compete with ATP. Reversible: no Target IC50: <50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Sequence Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂ Physical form Supplied as a trifluoroacetate salt. Reconstitution Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Swaroop, N., et al. 2001. Pharm. Res.18, 1631. Traenckner, E.B., et al. 1995. EMBO. J.14, 2876.