Description General description A thiophenecarbonitrile compound that acts as a potent ATP-competitive inhibitor of IKK-3 (IKK-ε, IC50 = 40 nM) with ~20-fold selectivity over PLK1 and more than 125-fold selectivity over a panel of 9 other commonly studied kinases, including IKK-1/2 (IKK-α/β). Reported to be inactive against cytochrome P450 isozymes (IC50< 50 µM) 1A2, 2D6, 2C9, and 3A4. Packaging 5 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target IKK-3 Product competes with ATP. Reversible: no Target IC50: 40 nM against IKK-3 (IKK-ε) Packaging Packaged under inert gas Warning Toxicity: Harmful (C) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Other Notes Bamborough, P., et al. 2006. Bioorg. Med. Chem. Lett.16, 6236.