Description General description Inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKCα-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction. Packaging 1 ml in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target PKC Product competes with ATP. Reversible: yes Target IC50: 7.9 nM, 2.3 nM, and 6.2 nM, for rat brain PKC, Ca2+-dependent PKC α-isozyme, and PKCβI, respectively Packaging Packaged under inert gas Warning Toxicity: Irritant (B) Physical form A 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO. Reconstitution Following initial thaw, aliquot and freeze (-20°C). Other Notes Gschwendt, M., et al. 1996. FEBS Lett.392, 77. Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun.200, 1536. Martiny-Baron, G., et al. 1993. J. Biol. Chem.268, 9194. Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA90, 674.; Description