Description General description A potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1); Ki = 0.5 nM for gelatinase A (MMP-2); Ki = 27 nM for stromelysin (MMP-3); Ki = 0.1 nM for neutrophil collagenase (MMP-8); and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice. Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target MMP-1 Product does not compete with ATP. Reversible: no Target Ki: 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9 Packaging Packaged under inert gas Warning Toxicity: Irritant (B) Physical form A 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364205) in DMSO. Reconstitution Following initial use, aliquot and refrigerate (4°C). Other Notes Solorzano, C.C., et al. 1997. Shock7, 427. Galardy, R.E., et al. 1994. Ann. NY Acad. Sci.732, 315. Galardy, R.E., et al. 1994. Cancer Res.54, 4715. Galardy, R.E., et al. 1993. Drugs Future18, 1109. Grobelny, D., et al. 1992. Biochemistry31, 7152.; Description