Description General description A cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 370 nM). Selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells. Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target cam kinase 2 Product does not compete with ATP. Reversible: no Packaging Packaged under inert gas Warning Toxicity: Irritant (B) Physical form A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO. Reconstitution Following initial thaw aliquot and freeze (-20°C). Other Notes Fan, G.H., et al. 1999. Mol. Pharmacol.56, 39. Tombes, R.M., et al. 1995. Cell Growth Differentiation6, 1063. Chen, C., et al. 1994. Science266, 291. Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608. Niki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968. Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.