Description General description A cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos. Packaging 50 μg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target Inhibitor of microfilament-mediated processes in sperm, eggs, and embryos Product does not compete with ATP. Reversible: no Packaging Packaged under inert gas Warning Toxicity: Harmful (C) Physical form A 1 mM (50 µg/119 µl) solution of Latrunculin A, Latrunculia magnifica Cat. No. 428021 in DMSO. Reconstitution Following initial use, aliquot and freeze (-20°C). Other Notes Ayscough, K.R., et al. 1997. J. Cell Biol.137, 399. Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127. Coue, M., et al. 1987. FEBS Lett.213, 316. Schatten, G., et al. 1986. Exp. Cell Res.166, 191. Spector, I., et al. 1983. Science219, 493.