Description General description A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. The solid form (Cat. No. 559285) is also available. Packaging 500 μg in Glass bottle Packaged under inert gas Warning Toxicity: Irritant (B) Physical form A 10 mM (500 µg/97 µl) solution of RSK Inhibitor, SL0101 (Cat. No. 559285) in DMSO. Reconstitution Following initial thaw, aliquot and freeze (-20°C). Other Notes Smith, J.A., et al. 2007. Bioorg. Med. Chem.15, 5018. Smith, J.A., et al. 2006. Bioorg. Med. Chem.14, 6043. Xu, Y.M., et al. 2006. Bioorg. Med. Chem.14, 3974. Maloney, D.J. and Hecht, S.M., 2005. Org. Lett.7, 1097. Smith, J.A., et al. 2005. Cancer Res.65, 1027.