Description_x000D_ Biochem/physiol Actions_x000D_ IP-10 (interferon-γ-inducible protein-10) protein is a proinflammatory chemokine which controls immune responses. It interacts with chemokine receptor 3 (CXCR3) and activates leukocytes including T cells, eosinophils, monocytes and natural killer cells. It is secreted by monocytes, neutrophils, endothelial cells, keratinocytes, fibroblasts, mesenchymal cells, dendritic cells, astrocytes and hepatocytes. Mutations in IP-10 are associated with rheumatoid arthritis. In humans with chronic hepatitis C virus (HCV) infection or HCV/human immunodeficiency virus (HIV) co-infection, IP-10 is linked with obesity and insulin resistance._x000D_ IP-10, a chemoattractant for activated T lymphocytes, is a potent inhibitor of angiogenesis and displays thymus-dependent anti-tumor effects. It is an ~8.7 kDa polypeptide of 78 amino acids. Human IP-10 shows 67% amino acid homology to mouse CRG-2._x000D_ Physical form_x000D_ Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose containing 50 μg bovine serum albumin per 1 μg of cytokine._x000D_ Analysis Note_x000D_ The biological activity is measured by its ability to chemoattract mouse BaF/3 cells transfected with hCXCR3.